Gastrointestinal Therapeutics
Patient-centered GC-C innovation for CIC and IBS-C
Synergy Pharmaceuticals develops evidence-based therapies including TRULANCE® (plecanatide) for adult patients with chronic idiopathic constipation and irritable bowel syndrome with constipation. Our teams combine clinical rigor with compassionate support programs.
Guidance for patients & caregivers
- What to expect from TRULANCE therapy
- Insurance coverage and co-pay assistance
- Diet, hydration, and lifestyle tips for CIC/IBS-C
Resources for prescribers
- Dosing guidance and titration considerations
- Clinical data, mechanism of action, and safety
- Prior authorization and access support details
Audience pathways
Clear entry points for every visitor
Patients, caregivers, and healthcare professionals reach tailored content immediately while staying aligned to FDA compliance and Important Safety Information.
Support before and during therapy
Understand CIC/IBS-C, how TRULANCE is taken, and where to find support when questions come up.
- Condition education with plain-language glossaries
- Step-by-step dosing expectations and adherence tips
- Access to co-pay assistance and coverage guidance
Clinical depth with concise access tools
Quickly reach indication-specific materials, safety communications, and payer support for TRULANCE.
- Mechanism of action and clinical outcomes
- ISI anchored on every page with full context
- Prior authorization language and reimbursement contacts
TRULANCE® (plecanatide)
Proven therapy for adult CIC and IBS-C
GC-C agonist approved for adult patients. Indication-specific details are available for both patients and healthcare professionals.
Indications and clinical profile
- Indicated for treatment of adults with chronic idiopathic constipation (CIC)
- Indicated for treatment of adults with irritable bowel syndrome with constipation (IBS-C)
- GC-C agonist mechanism that supports intestinal fluid secretion and motility
- Common adverse reaction: diarrhea; see Important Safety Information
Patient support
Access and adherence resources
Co-pay assistance, nurse-led education, and lifestyle content keep patients informed while reinforcing safety and adherence.
Co-pay & Coverage
Guidance for verifying coverage, estimating out-of-pocket costs, and activating available co-pay programs.
Check eligibility →Patient Education
Plain-language CIC/IBS-C education, FAQs, and tips to discuss with healthcare professionals.
Visit disease education →Adherence Resources
Reminders, expectations for onset, and when to contact a healthcare provider about side effects.
Patient checklist →Pipeline & Science
Advancing GC-C agonist science
Beyond TRULANCE, our research pipeline explores additional therapeutic applications for gastrointestinal diseases.
Dolcanatide & research platform
- Dolcanatide in clinical development for ulcerative colitis
- GC-C platform research exploring additional GI indications
- Commitment to rigorous clinical trials and transparent data
Latest updates
News, investors, and corporate responsibility
Stay informed on press releases, investor updates, and our commitment to responsible innovation.
Investor Relations
Corporate filings, leadership updates, and financial contacts for stakeholders.
Investor resources →Corporate Responsibility
Ethical conduct, patient safety, and community engagement.
See our commitments →Connect
Ready to talk with Synergy?
We are available for medical inquiries, access support, and partnership discussions.