Our Legacy of Innovation

Three decades of advancing gastrointestinal healthcare

Timeline of Achievement

1992: Founded

Synergy Pharmaceuticals established with vision to develop innovative GI therapies.

2017: FDA Approval CIC

Trulance approved for chronic idiopathic constipation treatment.

2018: FDA Approval IBS-C

Trulance expanded to include irritable bowel syndrome with constipation.

2019: Strategic Transition

Bausch Health acquisition ensures continued innovation and patient access.

Important Safety Information — TRULANCE® (plecanatide)

Indication

TRULANCE is indicated for the treatment of adults with chronic idiopathic constipation (CIC) and adults with irritable bowel syndrome with constipation (IBS-C).

Contraindications

TRULANCE is contraindicated in patients less than 6 years of age due to the risk of serious dehydration. Do not use in patients with known or suspected mechanical gastrointestinal obstruction.

Warnings & Precautions

Diarrhea is the most common adverse reaction. If severe diarrhea occurs, suspend dosing and contact a healthcare provider. Safety and efficacy have not been established in patients under 18 years of age; avoid use in pediatric patients.

Additional Information

Use TRULANCE only as prescribed. Discuss all medical conditions, medications, and pregnancy or breastfeeding considerations with a healthcare professional. See product pages for complete details.

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